Superantigens are a class of antigens that cause non-specific activation of T-cells and may have evolved as defense mechanisms of some pathogens against host immune responses. Responses to superantigens include polyclonal T-cell activation and massive release of cytokines, primarily interferon gamma. High levels of interferon gamma activate macrophages which produce proinflammatory cytokines such as IL-1, IL-6, and TNF-alpha that can result in shock and organ failure.
Data released by The World Health Organization (WHO) On July 7, 2017 revealed that cases of gonorrhoea are increasingly more difficult to treat due to widespread resistance to antibiotics that were traditionally used to treat those infections.
Monoclonal antibodies are extensively used in research laboratories, diagnostic products and immunotherapy and have multiple advantages over polyclonal antibodies. They exhibit enhanced specificity to single epitopes, have little or no variability, and are easy to modify and customize as required. Read the article on Bitesize Bio…
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
Rockwood N. et al. Frontiers in Immunology May 2017, Volume 8, Article 542 A newly published multi-author study offers new insights into the role of heme oxygenase-1 (HO-1) in the pathogenesis of tuberculosis (TB) and substantiates earlier proposals that HO-1 can be a useful biomarker of active TB infection. HO-1 expression was greatly increased in […]
SDS-PAGE (sodium dodecyl sulphate-polyacrylamide gel electrophoresis) is commonly used in the lab for the separation of proteins based on their molecular weight. It’s one of those techniques that is commonly used but not frequently fully understood. So let’s try and fix that. SDS-PAGE separates proteins according to their molecular weight, based on their differential rates […]
Successful western blotting means achieving unambiguous results, and this requires a sensitive and specific antibody-antigen interaction. Consequently, high quality antibodies are critical for reliable and consistent western blotting. Read the full article on BitesizeBio…
My phone’s email notification went off, and I rolled over in bed to look at the clock. Saturday, 5 am. Wonderful. Who would email me at that hour? It had to be my undergraduate research PI. I unlocked my phone. Yep. Doesn’t he ever sleep? Dear Casey: We are launching a new collaborative project in […]
They say “a picture is worth a thousand words.” This is especially true in the case of fluorescent immunohistochemistry (IHC). With the flip of a microscope filter, you can gaze into a brightly colored galaxy of red, green, and blue pixels, waiting to be captured and presented in your next publication. If you are interested in […]
The growing threat of antibiotic resistant bacteria has led researchers around the globe to look at ways to stop these ‘superbugs’. Researchers from McGill University in Montreal have presented in detail how specific bacterial enzymes called kinases, confer resistance to macrolide antibiotics—a widely used class of antibiotics and an alternative medication for patients with penicillin […]
A novel signaling pathway in which Heat Shock Protein 70 (Hsp70) plays a role has been added to its many well-established chaperone functions: a regulatory factor for the transition between stages of parasite development. The studies described by Ishida and Jolly support the conclusion that Hsp70 is involved in a signaling pathway that causes S. […]
- Superantigens Elicit “Cytokine Storm”: Responsible T-Cells Identified
- Antibiotic-resistant gonorrhoea on the rise
- Taking up the Challenges of In Vitro Monoclonal Antibody Production
- Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
- How SDS-PAGE works